Document Detail

Glycyrrhizin and glycyrrhetinic acid directly modulate rat cardiac performance.
MedLine Citation:
PMID:  21414764     Owner:  NLM     Status:  Publisher    
Root extract of liquorice is traditionally used to treat several diseases. Liquorice-derived constituents present several biological actions. In particular, glycyrrhizin and its aglycone, glycyrrhetinic acid, exhibit well-known cardiovascular properties. The aim of this research was to explore the direct cardiac activity of glycyrrhizin and glycyrrhetinic acid. The effects of synthetic glycyrrhizin and glycyrrhetinic acid were evaluated on the isolated and Langendorff perfused rat heart. The intracellular signaling involved in the effects of the two substances was analyzed on isolated and perfused heart and by Western blotting on cardiac extracts. Under basal conditions, both glycyrrhizin and glycyrrhetinic acid influenced cardiac contractility and relaxation. Glycyrrhizin induced significant positive inotropic and lusitropic effects starting from very low concentrations, while both inotropism and lusitropism were negatively affected by glycyrrhetinic acid. Both substances significantly increased heart rate. Analysis of the signal transduction mechanisms suggested that glycyrrhizin acts through the endothelin receptor type A/phospholipase C axis while glycyrrhetinic acid acts through endothelin receptor type B/Akt/nitric oxide synthase/nitric oxide axis. To our knowledge, these data reveal, for the first time, that both glycyrrhizin and glycyrrhetinic acid directly affect cardiac performance. Additional information on the physiological significance of these substances and their cardiac molecular targets may provide indication on their biomedical application.
Maria L Parisella; Tommaso Angelone; Alfonsina Gattuso; Maria C Cerra; Daniela Pellegrino
Related Documents :
15210364 - Synthesis and mesogenic properties of a y-shaped glyco-glycero-lipid.
7706934 - Uptake and compartmentalization of fluorescent lipid analogs in larval schistosoma mans...
192724 - Glucuronosyl-n-acetylglucosaminyl pyrophosphoryldolichol. formation in sv40-transformed...
3139924 - Neutral lipid storage disease with ichthyosis: lipid content and metabolism of fibrobla...
20816224 - The acidic environment of the golgi is critical for glycosylation and transport.
9570694 - Rhein affects arylamine n-acetyltransferase activity in helicobacter pylori from peptic...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  The Journal of nutritional biochemistry     Volume:  -     ISSN:  1873-4847     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010081     Medline TA:  J Nutr Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Cell Biology, University of Calabria, Arcavacata di Rende (CS), Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physiologic responses during the six minute walk test in obese and non-obese COPD patients.
Next Document:  Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the ...