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Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid.
MedLine Citation:
PMID:  23610519     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Glycyrrhizic acid (GA), the main component of radix glycyrrhizae, has a variety of pharmacological activities. In the present study, suspensions of GA nanoparticles with the average particle size about 200nm were prepared by a supercritical antisolvent (SAS) process. Comparative studies were undertaken using lipopolysaccardide(LPS)-stimulated mouse macrophages RAW 264.7 as in vitro inflammatory model. Several important inflammation mediators such as NO, PGE2, TNF-α and IL-6 were examined. These markers were highly stimulated by LPS and were inhibited both by nano-GA and unprocessed GA in a dose-dependent manner, especially PGE2 and TNF-α. However nano-GA and unprocessed GA inhibited NO only at a high concentration. In general, we found that GA nanoparticle suspensions exhibited much better anti-inflammatory activities compared to unprocessed GA.
Authors:
Wei Wang; Meng Luo; Yujie Fu; Song Wang; Thomas Efferth; Yuangang Zu
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Publication Detail:
Type:  Journal Article     Date:  2013-04-12
Journal Detail:
Title:  International journal of nanomedicine     Volume:  8     ISSN:  1178-2013     ISO Abbreviation:  Int J Nanomedicine     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101263847     Medline TA:  Int J Nanomedicine     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  1377-83     Citation Subset:  IM    
Affiliation:
Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Harbin, People's Republic of China ; Engineering Research Center of Forest Bio-Preparation, Northeast Forestry University, Harbin, People's Republic of China ; State Engineering Laboratory of Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin, People's Republic of China.
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