| Glycyrrhetinic acid protects mice from Staphylococcus aureus pneumonia. | |
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MedLine Citation:
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PMID: 22085765 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the present study, the antimicrobial activity of glycyrrhetinic acid (GA) against Staphylococcus aureus, and its influence on the production of S. aureus alpha-haemolysin (Hla) were investigated, along with the in vivo activity of GA against S. aureus-induced pneumonia. GA could not inhibit the growth of S. aureus, but the secretion of Hla by S. aureus was significantly inhibited by low concentrations of GA in a dose-dependent manner. Furthermore, in vivo data show that GA provides protection against staphylococcal pneumonia in a murine model system. |
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Authors:
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Hong-En Li; Jia-Zhang Qiu; Zhan-Qing Yang; Jing Dong; Jian-Feng Wang; Ming-Jing Luo; Juan Pan; Xiao-Han Dai; Yu Zhang; Bai-Lin Song; Xu-Ming Deng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: Fitoterapia Volume: - ISSN: 1873-6971 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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