Document Detail


Glycyrol Induces Apoptosis in Human Jurkat T Cell Lymphocytes via the Fas-FasL/Caspase-8 Pathway.
MedLine Citation:
PMID:  20717871     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
GLYCYRRHIZA URALENSIS (Leguminosae) has long been used to treat inflammatory ailments, such as gastric ulcers, arthritis, and rheumatism. From this traditional herbal plant, glycyrol, a coumestan with anti-bacterial and anti-inflammatory activities, was first isolated and synthesized to test its apoptosis-inducing properties in human Jurkat cells. Flow cytometry analysis indicated that glycyrol can arrest the cell cycle in S phase and subsequently induce apoptosis in both time- and dose-dependent manners. Consequently, it was shown that caspase-8 and -9 were involved in the activation of apoptosis after glycyrol treatment. Despite its known NF- κB inhibitory activity, glycyrol did not influence the prosurvival Bcl-2 and the proapoptotic Bax. Interestingly, glycyrol was revealed to enhance the Fas level independently from p53, which even slightly decreased. Thus, glycyrol acts in a similar manner as known cytostatic drugs and may have a potential as lead for the development of drugs for cancer treatment.
Authors:
Eun Myoung Shin; Sanghee Kim; Irmgard Merfort; Yeong Shik Kim
Publication Detail:
Type:  Journal Article     Date:  2010-08-17
Journal Detail:
Title:  Planta medica     Volume:  77     ISSN:  1439-0221     ISO Abbreviation:  Planta Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  242-7     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
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