| Glycoxidation and wound healing in diabetes: an interesting relationship. | |
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MedLine Citation:
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PMID: 21846325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired diabetic wound healing (WH) constitutes a serious diabetic complication with increased morbidity, mortality and health expenditure. The exact pathogenetic mechanisms have not been fully clarified. A variety of hyperglycemia and oxidative stress related factors, have been proposed, including advanced glycaction end products (AGE). The existing literature data, support the role of AGE in the pathogenesis of diabetic complications, namely micro- and macro- angiopathy which underlie delayed diabetic WH. In addition, a large body of evidence support a direct negative effect of AGE in the WH process by their interference with various components involved in the cascade following skin injury. Endogenously formed or exogenously derived AGE, in a similar manner, affect negatively the WH process in diabetes. It is obvious that further studies are needed to clarify the exact role of AGE in the impaired diabetic WH and offer possible new therapeutic strategies. |
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Authors:
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Melpomeni Peppa; Sotirios A Raptis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current diabetes reviews Volume: 7 ISSN: 1875-6417 ISO Abbreviation: Curr Diabetes Rev Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: 2012-01-19 Revised Date: 2012-04-23 |
Medline Journal Info:
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Nlm Unique ID: 101253260 Medline TA: Curr Diabetes Rev Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 416-25 Citation Subset: IM |
Affiliation:
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Endocrine Unit, Second Department. of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University Medical School, "Attikon" University Hospital, Greece. molypepa@otenet.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 2
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complications,
physiopathology* Diabetic Angiopathies / complications, physiopathology* Glycosylation End Products, Advanced / metabolism Humans Hyperglycemia / complications, physiopathology* Oxidative Stress Wound Healing* Wounds and Injuries / metabolism, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Glycosylation End Products, Advanced |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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