Document Detail


Glycotherapy for cancer: remodeling of ganglioside pattern as an effective approach for cancer therapy.
MedLine Citation:
PMID:  12102145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have found that an increase in the ganglioside GM3 is a prerequisite for the induction of terminal differentiation, cuhninating in death by apoptosis, of human colonic carcinoma cells in vitro. To evaluate the therapeutic effect of increasing GM3 in human colonic carcinoma cells, we examined whether treated cells lose their tumorigenic activity and whether this approach is effective against cancer cells growing in vivo. Cells of the human colonic carcinoma cell line HCT 116 not only differentiated but also lost their tumorigenic activity by an artificial increase in GM3. When HCT 116 tumors growing in nude mice were treated with a drug that increases GM3, an appreciable increase in GM3 and induction of apoptosis were clearly observed. The growth of treated tumors was greatly suppressed. These results suggest that the modulation of ganglioside expression to introduce gangliosides with biological activity into cancer cells could be a novel effective approach for cancer therapy.
Authors:
Hisao Nojiri; Hideaki Yamana; Genzan Shirouzu; Toshihide Suzuki; Hideo Isono
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer detection and prevention     Volume:  26     ISSN:  0361-090X     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-09     Completed Date:  2002-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-20     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Teikyo University, Tsukui-gun, Kanagawa, Japan. nojiri-h@pharm.teikyo-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy*,  metabolism,  pathology
Animals
Apoptosis / drug effects
Brefeldin A / therapeutic use*
Cell Differentiation
Cell Division
Colonic Neoplasms / drug therapy*,  metabolism,  pathology
G(M3) Ganglioside / metabolism*
Humans
In Situ Nick-End Labeling
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Transplantation
Tumor Cells, Cultured / drug effects
Chemical
Reg. No./Substance:
0/G(M3) Ganglioside; 20350-15-6/Brefeldin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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