| Glycotargeting to improve cellular delivery efficiency of nucleic acids. | |
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MedLine Citation:
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PMID: 17268860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acids bearing glycans of various structures have been under vigorous investigation in the past decade. The carbohydrate moieties of such complexes can serve as recognition sites for carbohydrate-binding proteins-lectins-and initiate receptor-mediated endocytosis. Therefore, carbohydrates can enhance cell targeting and internalization of nucleic acids that are associated with them and thus improve the bioavailability of nucleic acids as therapeutic agents. This review summarizes nucleic acid glycosylation in nature and approaches for the preparation of both non-covalently associated and covalently-linked carbohydrate-nucleic acid complexes. |
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Authors:
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Hongbin Yan; Kha Tram |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-02-01 |
Journal Detail:
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Title: Glycoconjugate journal Volume: 24 ISSN: 0282-0080 ISO Abbreviation: Glycoconj. J. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-02 Completed Date: 2007-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8603310 Medline TA: Glycoconj J Country: United States |
Other Details:
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Languages: eng Pagination: 107-23 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Brock University, 500 Glenridge Ave., St. Catharines, ON, Canada. tyan@brocku.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbohydrate Sequence Dendrimers / administration & dosage, chemical synthesis, chemistry Drug Delivery Systems / methods* Glycoconjugates / administration & dosage, chemical synthesis, chemistry Glycosylation Intercalating Agents Molecular Sequence Data Molecular Structure Nucleic Acids / administration & dosage*, chemical synthesis, chemistry* Oxidation-Reduction Polyamines / administration & dosage, chemical synthesis, chemistry Polylysine / administration & dosage, chemical synthesis, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Dendrimers; 0/Glycoconjugates; 0/Intercalating Agents; 0/Nucleic Acids; 0/Polyamines; 25104-18-1/Polylysine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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