Document Detail

Glycosynthase-catalysed formation of modified polysaccharide microstructures .
MedLine Citation:
PMID:  15182233     Owner:  NLM     Status:  MEDLINE    
Glycosynthases are mutant glycosidases, genetically engineered to catalyse the synthesis of oligosaccharides. A study by Faijes et al. in this issue of the Biochemical Journal has expanded the ability of glycosynthases to catalyse the polymerization of carbohydrates to form unnatural oligosaccharide products that can attain unique crystalline forms. These findings reinforce the potential of glycosynthases as interesting and important tools for the enzymic synthesis of novel carbohydrates with specific and controlled structures.
Andrew G Watts; Stephen G Withers
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  380     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-08     Completed Date:  2004-11-04     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  e9-10     Citation Subset:  IM    
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.
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MeSH Terms
Bacterial Proteins / chemistry,  genetics
Fungal Proteins / chemistry,  genetics
Genetic Engineering / methods,  trends
Glucosyltransferases / chemistry,  genetics
Glycoside Hydrolases / chemistry*,  genetics*
Mutagenesis, Site-Directed / genetics*
Oligosaccharides / biosynthesis
Polysaccharides / biosynthesis*
Reg. No./Substance:
0/Bacterial Proteins; 0/Fungal Proteins; 0/Oligosaccharides; 0/Polysaccharides; EC 2.4.1.-/Glucosyltransferases; EC 3.2.1.-/Glycoside Hydrolases
Comment On:
Biochem J. 2004 Jun 15;380(Pt 3):635-41   [PMID:  15038792 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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