| Glycosylation of serum proteins in inflammatory diseases. | |
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MedLine Citation:
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PMID: 19126970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammatory diseases are accompanied by numerous changes at the site of inflammation as well as many systemic physiological and biochemical changes. In the past two decades more and more attention is being paid to changes in glycosylation and in this review we describe some of the changes found on main serum proteins (alpha1-acid glycoprotein, immunoglobulin G, immunoglobulin A, transferrin, haptoglobin, alpha2-macroglobulin, C-reactive protein, and others). Molecular background and physiological importance of most of these changes are yet to be discovered, but it is evident that glycosylation plays an important role in the inflammatory response. Maybe the greatest value of these changes currently lays in their potential diagnostic and prognostic usage, either in combination with current diagnostic markers or on their own. However, determining glycan structures is still technically too complex for most clinical laboratories and further efforts have to be made to develop simple analytical tools to study changes in glycosylation. |
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Authors:
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Olga Gornik; Gordan Lauc |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Disease markers Volume: 25 ISSN: 0278-0240 ISO Abbreviation: Dis. Markers Publication Date: 2008 |
Date Detail:
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Created Date: 2009-01-07 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8604127 Medline TA: Dis Markers Country: Netherlands |
Other Details:
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Languages: eng Pagination: 267-78 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arthritis, Rheumatoid
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blood C-Reactive Protein / metabolism Carbohydrate Conformation Carbohydrate Sequence Gene Expression Regulation* Glycosylation Humans Immunoglobulin A / chemistry Immunoglobulin G / chemistry Inflammation / blood*, diagnosis* Lupus Erythematosus, Systemic / blood Molecular Sequence Data Orosomucoid / chemistry Pancreatitis / blood Sepsis |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin G; 0/Orosomucoid; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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