| Glycosylation of mouse and human immune cells: insights emerging from N-glycomics analyses. | |
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MedLine Citation:
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PMID: 21936811 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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N-glycans are key players mediating cell-cell communication in the immune system, interacting with glycan-binding proteins. In the present article, we discuss key themes that are emerging from the structural analysis of complex-type N-linked glycans from human and murine immune cell lines, employing high-sensitivity MALDI (matrix-assisted laser desorption ionization)-TOF (time-of-flight) MS technology. Particular focus is given to terminal epitopes, the abundance of multiply branched N-glycans and how glycosylation can affect human health in diseases such as congenital neutropenia and glycogen storage disease. |
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Authors:
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Aristotelis Antonopoulos; Simon J North; Stuart M Haslam; Anne Dell |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical Society transactions Volume: 39 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 1334-40 Citation Subset: IM |
Affiliation:
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Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, U.K. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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