Document Detail


Glycosylation of bisphenol A by freshwater microalgae.
MedLine Citation:
PMID:  17629547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endocrine disruptor bisphenol A (BPA, 4,4'-isopropylidenediphenol) is used to manufacture polycarbonate plastic and epoxy resin linings of food and beverage cans, and the residues from these products are then sometimes discharged into rivers and lakes in waste leachates. However, the fate of BPA in the environment has not yet been thoroughly elucidated. Considering the effect of BPA on aquatic organisms, it is important that we estimate the concentration of BPA and its metabolites in the aquatic environment, but there are few data on the metabolites of BPA. Here, we focused on freshwater microalgae as organisms that contribute to the biodegradation or biotransformation of BPA in aquatic environments. When we added BPA to cultures of eight species of freshwater microalgae, a reduction in the concentration of BPA in the culture medium was observed in all cultures. BPA was metabolized to BPA glycosides by Pseudokirchneriella subcapitata, Scenedesmus acutus, Scenedesmus quadricauda, and Coelastrum reticulatum, and these metabolites were then released into the culture medium. The metabolite from P. subcapitata, S. acutus, and C. reticulatum was identified by FAB-MS and (1)H-NMR as bisphenol A-mono-O-beta-d-glucopyranoside (BPAGlc), and another metabolite, from S. quadricauda, was identified as bisphenol A-mono-O-beta-d-galactopyranoside (BPAGal). These results demonstrate that freshwater microalgae that inhabit universal environments can metabolize BPA to its glycosides. Because BPA glycosides accumulate in plants and algae, and may be digested to BPA by beta-glycosidase in animal intestines, more attention should be given to levels of BPA glycosides in the environment to estimate the ecological impact of discharged BPA.
Authors:
Nobuyoshi Nakajima; Tetsuya Teramoto; Fumie Kasai; Tomoharu Sano; Masanori Tamaoki; Mitsuko Aono; Akihiro Kubo; Hiroshi Kamada; Yoshitaka Azumi; Hikaru Saji
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Publication Detail:
Type:  Journal Article     Date:  2007-07-16
Journal Detail:
Title:  Chemosphere     Volume:  69     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2008-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  934-41     Citation Subset:  IM    
Affiliation:
Environmental Biology Division, National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, Ibaraki 305-8506, Japan. naka-320@nies.go.jp
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MeSH Terms
Descriptor/Qualifier:
Algae* / drug effects,  growth & development,  metabolism
Biotransformation
Endocrine Disruptors / pharmacokinetics,  toxicity*
Food Chain
Fresh Water* / analysis,  microbiology
Glycosylation
Phenols / pharmacokinetics,  toxicity*
Water Pollutants, Chemical / pharmacokinetics,  toxicity*
Chemical
Reg. No./Substance:
0/Endocrine Disruptors; 0/Phenols; 0/Water Pollutants, Chemical; 80-05-7/bisphenol A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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