Document Detail

Glycosylated nordihydroguaiaretic acids as anti-cancer agents.
MedLine Citation:
PMID:  21123067     Owner:  NLM     Status:  In-Process    
Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.
Jih Ru Hwu; Chuan-I Hsu; Ming-Hua Hsu; Yu-Chuan Liang; Ru Chih C Huang; Yuan C Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-31
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  21     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  380-2     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Ltd.
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.
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