Document Detail


Glycosylated hemoglobin and protein levels in normal and diabetic pregnancies: relation to birth weight.
MedLine Citation:
PMID:  3515255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycosylated hemoglobin and protein were measured in maternal and cord blood of 24 normal, 19 class A, and ten insulin-treated diabetics using an affinity chromatographic technique. Maternal (intrapartum) glycohemoglobin and glycoprotein levels in the diabetics were not significantly different from those in normal controls, suggesting "tight" metabolic control in these patients. Compared with controls, cord blood glycohemoglobin and glycoprotein levels were significantly higher in insulin-treated, but not in class A, diabetics. The birth weight ratio correlated significantly only with maternal glycohemoglobin in insulin-treated diabetics. The results suggest that: even in well-controlled insulin-treated diabetics, the fetuses are hyperglycemic; maternal glycohemoglobin correlates with birth weight in insulin-treated diabetics; maternal glycoprotein determinations cannot be used to predict birth weight; hyperglycemia cannot be the sole determinant of fetal overgrowth in diabetic pregnancies; factors influencing fetal overgrowth in class A and insulin-treated diabetics may be different.
Authors:
H E Fadel; M M Elseweidy; E C Abraham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  67     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-04-28     Completed Date:  1986-04-28     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  533-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight*
Blood Proteins / analysis*
Body Weight
Female
Fetal Blood / analysis
Fetus / anatomy & histology
Gestational Age
Glycoproteins / blood
Hemoglobin A, Glycosylated / analysis*
Humans
Insulin / therapeutic use
Pregnancy*
Pregnancy in Diabetics / blood*,  drug therapy
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Glycoproteins; 0/Hemoglobin A, Glycosylated; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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