Document Detail


Glycosylated foldamers to probe the carbohydrate-carbohydrate interaction.
MedLine Citation:
PMID:  16910632     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate-carbohydrate interactions.
Authors:
Graham L Simpson; Andrew H Gordon; David M Lindsay; Netnepa Promsawan; Matthew P Crump; Keith Mulholland; Barry R Hayter; Timothy Gallagher
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  128     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-16     Completed Date:  2007-08-15     Revised Date:  2008-01-17    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10638-9     Citation Subset:  IM    
Affiliation:
School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
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MeSH Terms
Descriptor/Qualifier:
Carbohydrates / chemistry*
Glycosylation
Models, Molecular
Molecular Structure
Peptides / chemistry*
Protein Folding
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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