| Glycosylated carriers for cell-selective and nuclear delivery of nucleic acids. | |
| | |
MedLine Citation:
|
PMID: 21622215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Targeted gene delivery via selective cellular receptors has been realized as a crucial strategy for successful gene therapy by maximizing therapeutic efficiency in target cells and minimizing systemic toxicity. The membrane carbohydrate-binding proteins (membrane lectins) with different carbohydrate specificities are differentially expressed on the cellular and intracellular membranes of a number of cells. Their multiplicity, high affinity, and effective endocytosis after receptor binding as well as the biocompatibility of carbohydrate ligands endow them as potential ligands for glycosylated carriers in cell-selective delivery of nucleic acids. To achieve the in vivo application, glycosylated carriers/nucleic acid complexes have to fulfill certain conditions, including having a suitable size, minimal nonspecific interactions, low immunogenicity, and high uptake in target cells. Accordingly, the effective nuclear delivery of nucleic acids is the paramount important step for efficient gene transfer. This review summarizes the recent progress regarding application of glycosylated carriers for cell-selective and nuclear delivery of nucleic acids and their critical factors for efficient gene transfer. In addition, the development of new materials, such as carbon nanotubes, carbon nanospheres, and gold nanoparticles, as innovative carriers will be discussed with regards to glycosylation-mediated delivery of nucleic acids. |
| | |
Authors:
|
Wassana Wijagkanalan; Shigeru Kawakami; Mitsuru Hashida |
Related Documents
:
|
14983095 - Shift of fibril-forming ability of the designed alpha-helical coiled-coil peptides into... 15304635 - The ph of the secretory pathway: measurement, determinants, and regulation. 16133955 - Direct comparison of impedance, manometry, and ph probe in detecting reflux before and ... 1629565 - Determination of gastroduodenal alkaline responses using ph deflection in the rat. 141235 - A histochemical study of the mucus secretions of the rabbit colon. 637545 - Rapid test for the serological separation of staphylococci from micrococci. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-06-01 |
Journal Detail:
|
Title: Frontiers in bioscience : a journal and virtual library Volume: 17 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-05-30 Completed Date: 2011-10-03 Revised Date: 2012-01-10 |
Medline Journal Info:
|
Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
|
Languages: eng Pagination: 2970-87 Citation Subset: IM |
Affiliation:
|
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Nucleus / genetics Dendritic Cells / drug effects, metabolism Drug Carriers* / chemistry Endosomes / metabolism Gene Therapy / methods* Gene Transfer Techniques Glycosylation Hepatic Stellate Cells / drug effects, metabolism Hepatocytes / drug effects, metabolism Humans Lung / cytology, drug effects, metabolism Macrophages / drug effects, metabolism Models, Biological Neoplasms / genetics, therapy Nucleic Acids / administration & dosage*, genetics* Targeted Gene Repair / methods |
| Chemical | |
Reg. No./Substance:
|
0/Drug Carriers; 0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of EGFR and K-ras mutations for diagnosis of multiple lung adenocarcinomas.
Next Document: Nuclear receptors CAR and PXR; therapeutic targets for cholestatic liver disease.