Document Detail

Glycosylated Serum Protein May Improve Our Ability to Predict Endothelial and Erectile Dysfunction in Nonorganic Patients.
MedLine Citation:
PMID:  21143415     Owner:  NLM     Status:  Publisher    
Introduction.  Early prediction of erectile dysfunction (ED) is critical in the treatment of impotence. Underlying pathogenesis may be the reason for ED without organic causes in young men. Aim.  We evaluated the early predictive value of glycosylated serum protein (GSP) in young patients whose ED was diagnosed as "nonorganic" in origin according to general criteria. Methods.  A total of 150 young men with ED and 27 healthy men without ED were evaluated, including International Index of Erectile Function-5 (IIEF-5), causes of ED, influential or risk factors for ED, vascular parameters, and serum biochemical markers. Fifty-two ED patients aged 20-40 years without known etiology and 22 age-matched normal subjects were enrolled. The further assessment of two groups focused on vascular endothelial function and glycometabolic state. Main Outcome Measures.  Relationships among the IIEF-5 scores, flow-mediated dilation (FMD), and GSP were analyzed in cases vs. controls, using Pearson's correlation and multiple linear regression analysis. Results.  No significant differences in baseline characteristics, cardiovascular risks, and conventional biomarkers were found between testing and control groups, except fasting blood glucose level (4.69 ± 0.50 vs. 4.29 ± 0.48, P = 0.003). FMD values were significantly reduced in cases compared with controls and correlated positively with IIEF-5 scores (r = 0.629, P < 0.001). GSP levels were significantly increased in the ED cases compared with controls and correlated negatively with IIEF-5 scores (r = -0.504, P < 0.001) and FMD values (r = -0.469, P < 0.001). These parameters independently predicted ED presence. The positive predictive value of FMD > 11.55% for excluding ED and of GSP > 210.50 mg/L for diagnosing ED were 86.4% (area under the curve [AUC]: 0.942, specificity: 88.4%) and 84.5% (AUC: 0.864, specificity: 72.7%), respectively. Conclusions.  Underlying glycometabolic disorder and subclinical endothelial dysfunction may be served as early markers for organic ED in young ED patients without well-known related risk factors. GSP level may improve our ability to predict endothelial dysfunction and erectile dysfunction. Huang Y, Sun X, Liu G, Yao F, Zheng F, Dai Y, Tu X, Xie X, Deng L, Zhang D, Zhang Y, Bian J, Gao Y, Ye Y, Deng C, and Zhang Y. Glycosylated serum protein may improve our ability to predict endothelial and erectile dysfunction in non-organic patients. J Sex Med **;**:**-**.
Yanping Huang; Xiangzhou Sun; Guihua Liu; Fengjuan Yao; Fufu Zheng; Yuping Dai; Xiangan Tu; Xiaoyan Xie; Liwen Deng; Dingmei Zhang; Yadong Zhang; Jun Bian; Yong Gao; Yunlin Ye; Chunhua Deng; Yuanyuan Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-8
Journal Detail:
Title:  The journal of sexual medicine     Volume:  -     ISSN:  1743-6109     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230693     Medline TA:  J Sex Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2010 International Society for Sexual Medicine.
Department of Urology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Department of Ultrasonography, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yet-Sen University, Guangzhou, China Wake Forest University, Institute for Regenerative Medicine, Winston-Salem, NC, USA.
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