| Glycosphingolipids of subcellular fractions from normal rat liver and Morris hepatoma 5123TC. | |
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MedLine Citation:
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PMID: 283267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neutral glycosphingolipids and gangliosides were quantified in lipid extracts from plasma membranes, mitochondria, microsomes, and nuclei isolated from normal rat liver and Morris hepatoma 5123TC. Results showed a higher content of glycosphingolipids, especially gangliosides, in hepatomas and differences in the distribution of glycosphingolipids among subcellular fractions. Differences in the glycosphingolipid composition of the hepatoma, namely, the absence of trisialogangliosides and an increase in the lower molecular weight gangliosides, reflected an altered metabolism of glycosphingolipids in this tumor. The results indicated that changes in membrane glycosphingolipids were not restricted to the cell surfaces of malignant cells, inasmuch as intracellular membrane fractions also exhibited altered glycosphingolipid profiles. |
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Authors:
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A M Dnistrian; V P Skipski; M Barclay; C C Stock |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 62 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1979 Feb |
Date Detail:
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Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 367-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus / metabolism Gangliosides / metabolism Glycosphingolipids / metabolism* Liver / metabolism* Liver Neoplasms, Experimental / metabolism* Membrane Lipids / metabolism Microsomes, Liver / metabolism Mitochondria, Liver / metabolism Rats |
| Chemical | |
Reg. No./Substance:
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0/Gangliosides; 0/Glycosphingolipids; 0/Membrane Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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