| Glycosidic bond cleavage is not required for phytosteryl glycoside-induced reduction of cholesterol absorption in mice. | |
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MedLine Citation:
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PMID: 21538209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phytosteryl glycosides occur in natural foods but little is known about their metabolism and bioactivity. Purified acylated steryl glycosides (ASG) were compared with phytosteryl esters (PSE) in mice. Animals on a phytosterol-free diet received ASG or PSE by gavage in purified soybean oil along with tracers cholesterol-d(7) and sitostanol-d(4). In a three-day fecal recovery study, ASG reduced cholesterol absorption efficiency by 45 ± 6% compared with 40 ± 6% observed with PSE. Four hours after gavage, plasma and liver cholesterol-d(7) levels were reduced 86% or more when ASG was present. Liver total phytosterols were unchanged after ASG administration but were significantly increased after PSE. After ASG treatment both ASG and deacylated steryl glycosides (SG) were found in the gut mucosa and lumen. ASG was quantitatively recovered from stool samples as SG. These results demonstrate that ASG reduces cholesterol absorption in mice as efficiently as PSE while having little systemic absorption itself. Cleavage of the glycosidic linkage is not required for biological activity of ASG. Phytosteryl glycosides should be included in measurements of bioactive phytosterols. |
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Authors:
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Xiaobo Lin; Lina Ma; Robert A Moreau; Richard E Ostlund |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-05-03 |
Journal Detail:
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Title: Lipids Volume: 46 ISSN: 1558-9307 ISO Abbreviation: Lipids Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-08 Completed Date: 2011-11-14 Revised Date: 2012-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: Germany |
Other Details:
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Languages: eng Pagination: 701-8 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Ave., St. Louis, MO 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / metabolism* Chromatography, Gas / methods Feces / chemistry Glycosides / chemistry, metabolism* Humans Intestinal Absorption / physiology* Male Mass Spectrometry / methods Mice Mice, Inbred C57BL Phytosterols / chemistry, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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P30 DK056341-11/DK/NIDDK NIH HHS; P41 RR00954/RR/NCRR NIH HHS; R01 50420//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Glycosides; 0/Phytosterols; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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