| Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents. | |
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MedLine Citation:
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PMID: 19217081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oleanolic acid, a natural product, possesses an anti-osteoclast formation activity. Targeting at discovery of novel and potent anti-bone resorption agents, 22 glycosides of oleanolic acid derivatives (including d-galactopyranosides, d-glucopyranosides, d-xylopyranoses, d-arabopyranoses and d-glycuronic acids) were synthesized at phase-transfer-catalyzed conditions (K(2)CO(3), Bu(4)NBr, CH(2)Cl(2)-H(2)O) and their inhibitory activity on the formation of osteoclast-like multinucleated cells (OCLs) induced by 1alpha, 25-dihydroxy vitamin D(3) was evaluated in a co-culture assay system. The structure-activity relationships of these compounds were also discussed. |
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Authors:
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Jun-Feng Li; Song-Jie Chen; Yu Zhao; Jian-Xin Li |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-23 |
Journal Detail:
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Title: Carbohydrate research Volume: 344 ISSN: 1873-426X ISO Abbreviation: Carbohydr. Res. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-24 Completed Date: 2009-05-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043535 Medline TA: Carbohydr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 599-605 Citation Subset: IM |
Affiliation:
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Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow Cells / drug effects Cells, Cultured Galactose / chemistry Glucosides / chemistry Glycoconjugates / chemical synthesis*, chemistry, pharmacology* Glycosylation Magnetic Resonance Spectroscopy Male Mice Mice, Inbred ICR Molecular Structure Oleanolic Acid / analogs & derivatives*, chemistry* Osteoclasts / drug effects* Structure-Activity Relationship Vitamin D / analogs & derivatives, pharmacology Xylose / analogs & derivatives, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Glucosides; 0/Glycoconjugates; 0/Xylose; 0/xylopyranose; 1406-16-2/Vitamin D; 26566-61-0/Galactose; 508-02-1/Oleanolic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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