Document Detail


Glycoside-bearing liposomal delivery systems against macrophage-associated disorders involving Mycobacterium leprae and Mycobacterium tuberculosis.
MedLine Citation:
PMID:  7590855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asiaticoside, a plant glycoside with rhamnose as end sugar and having microbicidal properties was tested against Mycobacterium leprae and Mycobacterium tuberculosis both in vivo and in vitro. As rhamnose is reported to have no tissue specificity, corchorusin D having glucose as end sugar was used for targeting with an equimolar proportion of asiaticoside in liposomal form for testing the drug value. Results showed that liposomal asiaticoside had better microbicidal property against M. leprae and M. tuberculosis when compared to that of free asiaticoside whereas liposomes containing asiaticoside and corchorusin D were found to be equally or more active in comparison to liposomal asiaticoside alone. It is inferred that appropriate glycosides, if used in liposomal form (incorporated or covalently grafted) have enhanced drug efficacy and such glycoside bearing liposomes as targeted delivery systems could be used for chemotherapeutic control of several other diseases.
Authors:
S Medda; N Das; S B Mahato; P R Mahadevan; M K Basu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of biochemistry & biophysics     Volume:  32     ISSN:  0301-1208     ISO Abbreviation:  Indian J. Biochem. Biophys.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-28     Completed Date:  1995-11-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0310774     Medline TA:  Indian J Biochem Biophys     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Affiliation:
Biomembrane Division, Indian Institute of Chemical Biology, Jadavpur, Calcutta.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Carriers
Female
Leprosy / drug therapy*
Liposomes
Macrophages / drug effects*
Male
Mice
Mycobacterium leprae*
Mycobacterium tuberculosis*
Triterpenes / administration & dosage*
Tuberculosis / drug therapy*
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Liposomes; 0/Triterpenes; 16830-15-2/asiaticoside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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