Document Detail


Glycosaminoglycans in the synovial fluids of patients with juvenile rheumatoid arthritis.
MedLine Citation:
PMID:  1905599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple method was used to isolate hyaluronic acid (HA) and sulfated glycosaminoglycans from synovial fluids obtained from children with juvenile rheumatoid arthritis (JRA) and from normal age-matched controls. The bulk of the glycosaminoglycans present in both normal and pathologic synovial fluids consisted of hyaluronic acid and chondroitin 6-sulfate. The diseased synovial fluids showed a sharp decrease in the concentration of glycosaminoglycans when compared with normal controls. These findings are similar to those reported for the synovial fluid of adult patients with rheumatoid arthritis.
Authors:
P F Spelling; N Heise; O M Toledo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  9     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-08-06     Completed Date:  1991-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, University of São Paulo, School of Medicine, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Juvenile Rheumatoid / metabolism*
Chemical Fractionation
Chondroitin Sulfates / metabolism
Glycosaminoglycans / metabolism*
Humans
Hyaluronic Acid / metabolism
Osmolar Concentration
Reference Values
Synovial Fluid / metabolism*
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 9004-61-9/Hyaluronic Acid; 9007-28-7/Chondroitin Sulfates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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