Document Detail

Glycosaminoglycans in patellar cartilage.
MedLine Citation:
PMID:  2494839     Owner:  NLM     Status:  MEDLINE    
We obtained samples of patellar cartilage at the time of surgery from 20 patients: 11 with normal and 9 with macroscopic cartilaginous degeneration. The glycosaminoglycans were separated by cellulose acetate electrophoresis, and the relative content of major glycosaminoglycans was measured by optic scanning. The total content of glycosaminoglycans was estimated by uronic acid analysis. We found that degenerated cartilage contained an increase in dermatan sulfate and hyaluronic acid and a decrease in chondroitin 6-sulfate and total uronic acid concentration, with only slight changes in chondroitin 4-sulfate and keratan sulfate compared with normal cartilage.
E B Olsen; K Trier; H Møller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  60     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-05-03     Completed Date:  1989-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  23-5     Citation Subset:  IM    
Department of Dermatology, Rigshospital, University of Copenhagen, Denmark.
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MeSH Terms
Cartilage Diseases / metabolism
Cartilage, Articular / analysis*
Chondroitin Sulfates / analysis
Dermatan Sulfate / analysis
Electrophoresis, Cellulose Acetate
Glycosaminoglycans / analysis*
Hyaluronic Acid / analysis
Keratan Sulfate / analysis
Middle Aged
Uronic Acids / analysis
Reg. No./Substance:
0/Glycosaminoglycans; 0/Uronic Acids; 24967-94-0/Dermatan Sulfate; 9004-61-9/Hyaluronic Acid; 9007-28-7/Chondroitin Sulfates; 9056-36-4/Keratan Sulfate

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