Document Detail

Glycosaminoglycans and hydroxyproline in urine of rats exposed to simulated altitude of 725 hPa.
MedLine Citation:
PMID:  7246208     Owner:  NLM     Status:  MEDLINE    
Adult male rats were individually accustomed to experimental conditions in 16X16X30 cm polymethacrylate chambers. Each of 12 rats was twice subjected during 5 hrs or 5 1/2 hrs to hypobarism at a simulated altitude of 3000 m (725 Hpa). The amounts of total glycosaminoglycans (GAG) and hydroxyproline (Hp) were determined in urine portions collected during the period of hypobaric exposure and during the remaining part of the day. Transient shock-like symptoms with high excitement and seizures occurred in 2 of 12 rats during reduction of air pressure for the first time and a significant augmentation of urinary GAG output was found in both rats during this hypobaric period. The remaining rats showed only slight dysbaric signs in the tympanic cavity during ascending to simulated altitude and return to environmental air pressure in the hypobaric chamber. These animals excreted lower amounts of GAG during the hypobaric periods and higher amounts of Hp during the next days after hypobarism.
H Mikołajczyk; B Pach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Polonica     Volume:  32     ISSN:  0044-6033     ISO Abbreviation:  Acta Physiol Pol     Publication Date:    1981 Jan-Feb
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985166R     Medline TA:  Acta Physiol Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM; S    
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MeSH Terms
Adaptation, Physiological
Aerospace Medicine*
Air Pressure*
Atmospheric Pressure*
Glycosaminoglycans / urine*
Hydroxyproline / urine*
Time Factors
Reg. No./Substance:
0/Glycosaminoglycans; 51-35-4/Hydroxyproline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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