Document Detail


Glycosaminoglycans and glycoproteins in bronchoalveolar lavage fluid from patients with pulmonary alveolar proteinosis.
MedLine Citation:
PMID:  6654474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bronchoalveolar lavage fluid from two cases of pulmonary alveolar proteinosis were analyzed for glycosaminoglycans and glycoproteins. The clinical courses of the two cases were entirely different. In one patient, signs and symptoms recurred despite repeated therapeutic bronchoalveolar lavages. In the other patient, three successive bronchoalveolar lavages brought about complete recovery. It was found that the bronchoalveolar lavage fluid from the former case contained various subtypes of glycosaminoglycans [hyaluronic acid, chondroitin sulfate A(C), dermatan sulfate, and heparan sulfate] and glycoprotein. On the other hand, the bronchoalveolar lavage fluid from the latter case contained glycoprotein, but no detectable amounts of glycosaminoglycans. There was only a slight qualitative difference in glycoprotein of bronchoalveolar lavage fluid between the two cases. The presence or absence of glycosaminoglycans in bronchoalveolar lavage fluid may be related to the prognosis of pulmonary alveolar proteinosis.
Authors:
K Satoh; H Arai; T Yoshida; M Ito; H Nagai; H Sato; M Motomiya; K Konno
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Inflammation     Volume:  7     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromatography, Ion Exchange
Electrophoresis, Cellulose Acetate
Female
Glycoproteins / analysis*
Glycosaminoglycans / analysis*
Humans
Irrigation
Lung Diseases, Obstructive / physiopathology*,  therapy
Male
Middle Aged
Pulmonary Alveoli / analysis*
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Glycosaminoglycans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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