| Glycosaminoglycan excretion in children with nephrotic syndrome. | |
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MedLine Citation:
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PMID: 15714313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although most childhood nephrotic syndromes respond to steroid treatment, steroid resistant nephrotic syndrome (SRNS) is also common and is particularly difficult to treat. This study investigated the role of glycosaminoglycans (GAG) in the pathogenesis and clinical course of nephrotic syndrome in children. Thirty-four children (21 males and 13 females, mean age 3.7+/-1.6 years) with steroid-sensitive nephrotic syndrome and 20 children with steroid-resistant nephrotic syndrome (12 males and 8 females, mean age 10.9+/-3.8 years; of the twenty, four had primary SRNS (FSGS) and the others had secondary SRNS) were included the study. Mean urine levels of GAG relative to creatinine (U(GAG)/U(Cr)) in patients with SRNS (n=20, 113.01+/-78.46 mg g(-1) Cr) and in patients experiencing the nephrotic period of steroid-sensitive nephrotic syndrome (n=34, 132.15+/-101.55 mg g(-1) Cr) were both significantly higher than mean U(GAG)/U(Cr) for control subjects (n=30, 51.83+/-47.66 mg g(-1) Cr) (P<0.01 for both). Patients excreted significantly more GAG during the nephrotic period of steroid-sensitive nephrotic syndrome than during remission (132.15+/-101.55 vs 39.11+/-42.73 mg g(-1) Cr, respectively; P<0.01). There was, however, no significant difference between U(GAG)/U(Cr) for patients with steroid-resistant nephrotic syndrome and U(GAG)/U(Cr) in the nephrotic period of steroid-sensitive nephrotic syndrome. Urine GAG excretion correlated significantly with the severity of proteinuria. The results suggest that GAG play a significant role in the pathogenesis of nephrotic syndrome but that GAG excretion is not a marker for response to steroid treatment in pediatric patients with this condition. |
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Authors:
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Nurcan Cengiz; Aysun K Bayazit; Aytul Noyan; Ruksan Anarat; Ali Anarat |
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Publication Detail:
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Type: Journal Article Date: 2005-02-16 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 20 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-04 Completed Date: 2005-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 486-90 Citation Subset: IM |
Affiliation:
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Adana Teaching and Medical Research Center, Department of Pediatric Nephrology, Baskent University Faculty of Medicine, Seyhan Hospital, 01140 Adana, Turkey. nurcem@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Case-Control Studies Child Child, Preschool Creatinine / urine Drug Resistance Female Glycosaminoglycans / urine* Humans Male Nephrotic Syndrome / drug therapy, urine* Proteinuria / physiopathology Severity of Illness Index Steroids / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Glycosaminoglycans; 0/Steroids; 60-27-5/Creatinine |
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