Document Detail

Glycosaminoglycan components in duodenum with advancing age and in patients with progressive systemic sclerosis.
MedLine Citation:
PMID:  7657049     Owner:  NLM     Status:  MEDLINE    
The glycosaminoglycan (GAG) components in normal human duodenal tissue and in duodenal GAGs of patients with progressive systemic sclerosis (PSS) were characterized at the macromolecular level by electrophoresis combined with various GAG-specific digestion. High-performance liquid chromatographic assay quantified various unsaturated disaccharides derived from chondroitin sulfate and dermatan sulfate isomers (DS). The data obtained showed that on average, the total GAG content was 1.02 mg as uronic acid/g dry tissue weight, and the main GAGs were DS (33% of total GAGs), and heparan sulfates (HS, 27%), followed by hyaluronic acid (HA, 14%) and over-sulfated DS (10%), and small amounts of chondroitin, chondroitin-4- and -6-sulfates (C-4S and C-6S, totally 16%). With advancing age, the proportion of DS, HS and oversulfated DS increased, while HA, chondroitin and C-4S decreased. The composition of duodenal GAGs in PSS patients was similar to that in the aged: a higher proportion of DS isomers and HS and a lower proportion of HA and chondroitin. As the structure of sulfated GAGs differs with advancing age and in patients with PSS, GAGs may have a role in duodenal function and metabolism.
K Murata; T Sekino; T Ikeda; Y Yokoyama
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestion     Volume:  56     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1995  
Date Detail:
Created Date:  1995-09-29     Completed Date:  1995-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  230-6     Citation Subset:  IM    
Medical Center, Tokyo National University of Fine Arts, Ueno Park, Japan.
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MeSH Terms
Aged, 80 and over
Aging / metabolism*
Child, Preschool
Chromatography, High Pressure Liquid
Chromatography, Paper
Duodenum / metabolism*
Glycosaminoglycans / metabolism*
Middle Aged
Scleroderma, Systemic / metabolism*
Reg. No./Substance:

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