Document Detail

Glycopyrrolate in children.
MedLine Citation:
PMID:  7317246     Owner:  NLM     Status:  MEDLINE    
The effects of glycopyrrolate 10 microgram kg-1 i.v. given at induction of anaesthesia were compared with those of atropine 20 microgram kg-1 i.v. given at induction and oral atropine 30 microgram kg-1 given 90 min before operation. Antisialagogue effect, changes in axillary temperature, heart rate, frequency of cardiac arrhythmia and postoperative restlessness were determined. Patients who had received oral atropine had more pharyngeal secretions, a lower heart rate and a greater frequency of cardiac arrhythmia than when either atropine or glycopyrrolate was given i.v. Secretions were significantly less during operation when i.v. glycopyrrolate was used.
P Warran; P Radford; M L Manford
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  53     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-26     Completed Date:  1982-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1273-6     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Atropine / administration & dosage,  pharmacology
Body Temperature / drug effects
Child, Preschool
Depression, Chemical
Glycopyrrolate / pharmacology*
Heart Rate / drug effects
Injections, Intravenous
Preanesthetic Medication*
Pyrrolidines / pharmacology*
Salivation / drug effects
Reg. No./Substance:
0/Pyrrolidines; 51-55-8/Atropine; 596-51-0/Glycopyrrolate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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