| Glycoprotein IIb/IIIa inhibitor (tirofiban) in acute ST-segment elevation myocardial infarction. | |
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MedLine Citation:
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PMID: 18445614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies have shown conflicting results for glycoprotein IIb/IIIa inhibitor (tirofiban) use in ST-segment elevation myocardial infarction (STEMI). The authors aimed to determine if an upstream conventional dose of tirofiban in addition to a standard treatment regimen improved coronary patency and clinical outcomes in patients with STEMI. A retrospective analysis of consecutive patients with STEMI, who underwent emergent percutaneous coronary intervention (PCI) in the authors' hospital from July 2000 to April 2006 was performed. All patients received loading doses of aspirin, clopidogrel or ticlopidine, and unfractionated heparin with or without tirofiban in the emergency department prior to PCI. It was found that adding a conventional dose of tirofiban to the standard treatment regimen prior to PCI did not improve coronary patency in STEMI patients. Tirofiban also failed to show favorable outcomes for 90 days of follow-up, but there was a favorable trend for short-term 30-day survival. |
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Authors:
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Ching-Chang Fang; Yeun Tarl Fresner Ng Jao; Yi Chen; Ching-Lung Yu; Shih-Pu Wang |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-04-29 |
Journal Detail:
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Title: Angiology Volume: 60 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2009 Apr-May |
Date Detail:
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Created Date: 2009-04-20 Completed Date: 2009-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 192-200 Citation Subset: IM |
Affiliation:
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Cardiovascular Center, Tainan Municipal Hospital, Tainan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Coronary Angiography Dose-Response Relationship, Drug Electrocardiography* Female Follow-Up Studies Humans Infusions, Intravenous Male Middle Aged Myocardial Infarction / mortality, radiography, therapy* Platelet Aggregation Inhibitors / administration & dosage, therapeutic use* Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors* Retrospective Studies Survival Rate Taiwan / epidemiology Treatment Outcome Tyrosine / administration & dosage, analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 144494-65-5/tirofiban; 55520-40-6/Tyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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