Document Detail


Glycophorin A is a potential biomarker for the mutagenic effects of pesticides.
MedLine Citation:
PMID:  15473078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For individuals with multiple exposures to bone marrow mutagens the glycophorin A (GPA) assay appears to detect the cumulative genotoxic effects of these nonspecific exposures. To determine whether workers exposed to organophosphates and/or carbamate pesticides have more GPA variants compared with controls, this cross-sectional cohort study examined 67 Latino farm workers, most of whom were exposed to organophosphate or carbamate pesticides, and 68 age-, gender-, ethnicity-, and education-matched reference subjects. Of the 27 participants who completed the questionnaire and had the M/N alleleotype required for the GPA assay, the N/N variant frequency was 9.1 x 10(-6) in the ten subjects with more than 1,500 cumulative hours of exposure vs 3.8 x 10(-6) in the six referent subjects with no known pesticide exposure (p = 0.097). A consistent trend with increasing cumulative exposure was found for N/N and O/N allele-loss frequencies when exposures were stratified into three groups. Despite the small sample size due to the alleleotype restriction, these findings support the hypothesis that some pesticides are mutagenic to hematopoietic stem cells.
Authors:
Tim K Takaro; Lawrence S Engel; Matthew Keifer; William L Bigbee; Terrance J Kavanagh; Harvey Checkoway
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of occupational and environmental health     Volume:  10     ISSN:  1077-3525     ISO Abbreviation:  Int J Occup Environ Health     Publication Date:    2004 Jul-Sep
Date Detail:
Created Date:  2004-10-11     Completed Date:  2005-03-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9505217     Medline TA:  Int J Occup Environ Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-61     Citation Subset:  IM    
Affiliation:
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA. ttakaro@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Agriculture
Biological Markers / blood
Carbamates / toxicity
Cohort Studies
Cross-Sectional Studies
Female
Genotype
Glycophorin / analysis,  genetics*
Hispanic Americans
Humans
Male
Mutagenicity Tests
Mutagens / toxicity*
Occupational Exposure / adverse effects
Pesticides / toxicity*
Phosphoric Acid Esters / toxicity
Smoking / adverse effects
Grant Support
ID/Acronym/Agency:
CA-91-20/CA/NCI NIH HHS; P30ES0733/ES/NIEHS NIH HHS; T32 ES07262/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Carbamates; 0/Glycophorin; 0/Mutagens; 0/Pesticides; 0/Phosphoric Acid Esters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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