Document Detail


Glycomics: towards bioinformatic approaches to understanding glycosylation.
MedLine Citation:
PMID:  18220504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell surface glycoconjugates control a variety of biological events including cell differentiation, homing to specific tissues, cell adhesion, virus/cell recognition and immunological recognition. The heterogeneity and diversity of these molecules present a challenge to understanding both their functions and how those functions are encoded. Advances in biotechnology have led to new methods for genome and proteome study that allow for the analysis of the entire genetic or protein content of a cell. Efforts towards the systematic study of the variations in cellular glycoconjugates are, in contrast, in their infancy. Recent advances in glycosylation related technology have begun to open up the possibility of exploring both the structure and the functions of the glycome in a systematic manner. This review focuses on the latest mass spectrometry, microarray-based and computational technologies for glycomics.
Authors:
Lara K Mahal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Anti-cancer agents in medicinal chemistry     Volume:  8     ISSN:  1871-5206     ISO Abbreviation:  -     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265649     Medline TA:  Anticancer Agents Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  37-51     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712-0265, USA. lmahal@cm.utexas.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrate Conformation
Carbohydrate Metabolism*
Computational Biology / methods*
Glycomics / methods*
Glycoproteins / metabolism*
Glycosylation
Humans
Lectins / metabolism
Mass Spectrometry
Microarray Analysis
Neoplasms* / diagnosis,  metabolism,  therapy
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Lectins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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