Document Detail

Glycolipid and glycoprotein expression during neural development.
MedLine Citation:
PMID:  25151380     Owner:  NLM     Status:  In-Data-Review    
In mammals, the central and peripheral nervous systems are developmentally derived from cells in the neural plate. Specific ectodermal cells in this area form the neural tube and neural crest during the early developmental stage. The neural tube is the origin of the central nervous system which consists of both the brain and spinal cord, whereas neural crest cells are precursors of the peripheral nervous system. During neural tube formation and neural crest development, carbohydrate-rich molecules, including glycolipids, glycoproteins, and proteoglycans, are expressed primarily on the outer surface of cell plasma membranes. The structural diversity of their carbohydrate moieties coupled with their expression at different stages of development makes these molecules excellent biomarkers for various cell types. In addition, these molecules play crucial functional roles in cell proliferation, differentiation, interaction, migration, and signal transduction. In this chapter, we discuss the expression profiles and potential functional roles of glycoconjugates during neural development.
Robert K Yu; Yutaka Itokazu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in neurobiology     Volume:  9     ISSN:  2190-5215     ISO Abbreviation:  Adv Neurobiol     Publication Date:  2014  
Date Detail:
Created Date:  2014-08-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101571545     Medline TA:  Adv Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-222     Citation Subset:  IM    
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