Document Detail

Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study.
MedLine Citation:
PMID:  9145958     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Treatment of postinflammatory hyperpigmentation in patients of Fitzpatrick skin types IV, V, and VI is difficult. Glycolic acid peels are useful for pigment dyschromias in caucasians; however, there are no controlled studies examining their safety and efficacy in dark-complexioned individuals. OBJECTIVE: To determine if serial glycolic acid peels provide additional improvement when compared with a topical regimen of hydroquinone and tretinoin. METHODS: Nineteen patients with Fitzpatrick skin type IV, V, or VI were randomized to a control or peel group. The control group applied 2% hydroquinone/10% glycolic acid gel twice daily and 0.05% tretinoin cream at night. The peel patients used the same topical regimen and, in addition, received six serial glycolic acid peels (68% maximum concentration). Patients were evaluated with photography, colorimetry, and subjectively. RESULTS: Sixteen patients completed the study. Both treatment groups demonstrated improvement, but the patients receiving the glycolic acid peels showed a trend toward more rapid and greater improvement. The peel group also experienced increased lightening of the normal skin. CONCLUSIONS: This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark-complexioned individuals.
R L Burns; P L Prevost-Blank; M A Lawry; T B Lawry; D T Faria; D P Fivenson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  23     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-02     Completed Date:  1997-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-4; discussion 175     Citation Subset:  IM    
Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
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MeSH Terms
Administration, Topical
African Continental Ancestry Group*
Dermatitis / complications*
Drug Combinations
Glycolates / administration & dosage*
Hydroquinones / administration & dosage
Hyperpigmentation / etiology,  therapy*
Keratolytic Agents / administration & dosage
Middle Aged
Pilot Projects
Tretinoin / administration & dosage
Reg. No./Substance:
0/Drug Combinations; 0/Glycolates; 0/Hydroquinones; 0/Keratolytic Agents; 123-31-9/hydroquinone; 302-79-4/Tretinoin; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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