| Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study. | |
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MedLine Citation:
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PMID: 9145958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Treatment of postinflammatory hyperpigmentation in patients of Fitzpatrick skin types IV, V, and VI is difficult. Glycolic acid peels are useful for pigment dyschromias in caucasians; however, there are no controlled studies examining their safety and efficacy in dark-complexioned individuals. OBJECTIVE: To determine if serial glycolic acid peels provide additional improvement when compared with a topical regimen of hydroquinone and tretinoin. METHODS: Nineteen patients with Fitzpatrick skin type IV, V, or VI were randomized to a control or peel group. The control group applied 2% hydroquinone/10% glycolic acid gel twice daily and 0.05% tretinoin cream at night. The peel patients used the same topical regimen and, in addition, received six serial glycolic acid peels (68% maximum concentration). Patients were evaluated with photography, colorimetry, and subjectively. RESULTS: Sixteen patients completed the study. Both treatment groups demonstrated improvement, but the patients receiving the glycolic acid peels showed a trend toward more rapid and greater improvement. The peel group also experienced increased lightening of the normal skin. CONCLUSIONS: This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark-complexioned individuals. |
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Authors:
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R L Burns; P L Prevost-Blank; M A Lawry; T B Lawry; D T Faria; D P Fivenson |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Volume: 23 ISSN: 1076-0512 ISO Abbreviation: Dermatol Surg Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-06-02 Completed Date: 1997-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9504371 Medline TA: Dermatol Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 171-4; discussion 175 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult African Continental Ancestry Group* Chemexfoliation* Dermatitis / complications* Drug Combinations Female Glycolates / administration & dosage* Humans Hydroquinones / administration & dosage Hyperpigmentation / etiology, therapy* Keratolytic Agents / administration & dosage Middle Aged Pilot Projects Tretinoin / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Glycolates; 0/Hydroquinones; 0/Keratolytic Agents; 123-31-9/hydroquinone; 302-79-4/Tretinoin; 79-14-1/glycolic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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