Document Detail

Glycolic acid peels in the treatment of melasma among Asian women.
MedLine Citation:
PMID:  9145959     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Melasma is a common disorder of facial hyperpigmentation among Asian women. Many modalities of treatment are available but none is satisfactory. OBJECTIVE: This study was undertaken to see if glycolic acid peels are effective and safe in the treatment of melasma and fine facial wrinkling. METHODS: Ten Asian women with moderate to severe melasma were recruited into the study. The women had twice daily applications of a cream containing 10% glycolic acid and 2% hydroquinone (Neostrata AHA Age Spot and Skin Lightening Gel) to both sides of the face, and glycolic acid peels every 3 weeks (20-70%) to one-half of the face using Neostrata Skin Rejuvenation System. All patients had to use a sunblock (SPF 15%). At regular intervals and at the end of 26 weeks (or after eight peels) the degree of improvement of pigmentation and fine facial wrinkling on each side of the face were assessed. Any skin irritation or side effects were also noted. Assessment was by an independent dermatologist, the patients themselves, and the use of the Munsell color chart and photographs. The nonparametric Wilcoxon Rank-Sum test was used for statistical analysis. RESULTS: The melasma and fine facial wrinkling improved on both sides of the face. The side that received glycolic acid peels did better but the results were not statistically significant (P > 0.059). CONCLUSION: A cream containing 10% glycolic acid and 2% hydroquinone (Neostrata AHA Age Spot and Skin Lightening Gel) improved melasma and fine facial wrinkling in Asian women. In combination with glycolic acid peels at 3-week intervals the lightening of melasma is subjectively much better. This improvement does not reach statistical significance and the sample size is small (n = 10).
J T Lim; S N Tham
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  23     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-02     Completed Date:  1997-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  177-9     Citation Subset:  IM    
National Skin Centre, Singapore.
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MeSH Terms
Administration, Topical
Asian Continental Ancestry Group*
Drug Combinations
Glycolates / administration & dosage*
Hydroquinones / administration & dosage
Melanosis / therapy*
Middle Aged
Single-Blind Method
Reg. No./Substance:
0/Drug Combinations; 0/Glycolates; 0/Hydroquinones; 123-31-9/hydroquinone; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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