Document Detail

Glycolic acid peels versus amino fruit acid peels in the treatment of melasma.
MedLine Citation:
PMID:  20187899     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chemical peels are becoming more popular as a treatment modality for melasma. OBJECTIVE: To compare the therapeutic effects of glycolic acid (GA) peels and amino fruit acid (AFA) peels in patients with melasma. METHODS: In this single-blind, randomized right-left comparison study, patients received 12 serial peels on the two halves of the face at 2-week intervals for 6 months. Clinical evaluation based on the modified Melasma Area and Severity Index (MASI) scores was performed at baseline and at 3 and 6 months. RESULTS: The modified MASI scores at 3 and 6 months in both application areas decreased significantly from baseline (p<.05). When the two applications were compared with each other, there was no statistically significant difference between GA and AFA in terms of regression of melasma (p>.05). During the application, it was observed that AFA peels caused fewer problems than GA peels did. CONCLUSIONS: Based on the results of this study, GA and AFA peels for melasma therapy were efficacious, but the AFA peel was found to be less irritating and was better tolerated.
Turna Ilknur; Mehtap Unl? Bi?ak; Melda Demirta?o?lu; Sebnem Ozkan
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-02-19
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  36     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-5     Citation Subset:  IM    
Department of Dermatology, Faculty of Medicine, Dokuz Eyl?l University, Izmir, Turkey.
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MeSH Terms
Administration, Cutaneous
Amino Acids / administration & dosage*
Chemexfoliation / methods*
Follow-Up Studies
Glycolates / administration & dosage*
Keratolytic Agents / administration & dosage*
Melanosis / therapy*
Middle Aged
Single-Blind Method
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Amino Acids; 0/Glycolates; 0/Keratolytic Agents; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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