| Glycogenic hepatopathy: a rare cause of elevated serum transaminases in diabetes mellitus. | |
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MedLine Citation:
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PMID: 20009116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycogenic hepatopathy (GH) is a rare cause of serum transaminase elevations in type 1 diabetes mellitus (DM). We describe a 29-year-old woman with a history of poorly controlled type 1 DM who presented with hepatomegaly and severe transaminase flares. Liver histology confirmed GH, with glycogen accumulation due to severe fluctuations in both glucose and insulin. GH can be regarded as an adult variant of Mauriac's syndrome. Despite severe laboratory abnormalities, it does not cause liver cirrhosis. Treatment consists of improving glycaemic control. |
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Authors:
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M van den Brand; L D Elving; J P H Drenth; J H J M van Krieken |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 67 ISSN: 1872-9061 ISO Abbreviation: Neth J Med Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 394-6 Citation Subset: IM |
Affiliation:
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Departments of Pathology, Radboud University Nijmegen Medical Centre Nijmegen, the Netherlands. m.brand@pathol.umcn.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood* Aspartate Aminotransferases / blood* Biopsy Causality Diabetes Mellitus, Type 1 / complications*, prevention & control Diagnosis, Differential Fatty Liver, Alcoholic / etiology Female Humans Liver Diseases / diagnosis, epidemiology, etiology*, metabolism* Liver Function Tests Liver Glycogen / metabolism* Prognosis Rare Diseases |
| Chemical | |
Reg. No./Substance:
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0/Liver Glycogen; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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