Document Detail

Glycogen resynthesis and exercise performance with the addition of fenugreek extract (4-hydroxyisoleucine) to post-exercise carbohydrate feeding.
MedLine Citation:
PMID:  17710365     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the effect of adding fenugreek extract (FG) to post-exercise carbohydrate feeding on glycogen resynthesis and subsequent exercise performance in normoglycemic male endurance athletes. A muscle biopsy sample was obtained from the vastus lateralis from subjects prior to exercise for 5 h at 50% of peak cycling power (52.1 +/- 3.3% of VO(2) peak). A second muscle biopsy sample was obtained immediately after exercise. Immediately after and 2 h after the second biopsy subjects ingested either an oral dose of dextrose (GLU) (1.8 g x kg BW(-1)) or GLU with FG containing 1.99 +/- 0.20 mg x kg(-1) 4-hydroxyisoleucine (GLU + FG) in a randomized, cross-over, double blind design. At 4 h post-exercise a third biopsy was taken and subjects received a standardised meal along with FG or a placebo capsule. At 15 h post-exercise subjects underwent their final muscle biopsy before completing a simulated 40 km cycling time trial. There was no difference in muscle glycogen at any time between GLU and GLU + FG. Additionally, 40 km time trial performance was similar for average power output (221 +/- 28 vs. 213 +/- 16 watts) and for time to completion (69.7 +/- 3.7 vs. 70.5 +/- 2.2 min) for the GLU and GLU + FG, respectively. Despite earlier data to the contrary, the present results do not support an effect of fenugreek supplementation on glycogen resynthesis, even though this may have been the result of differences in experimental protocol.
D Slivka; J Cuddy; W Hailes; S Harger; B Ruby
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Publication Detail:
Type:  Journal Article     Date:  2007-08-21
Journal Detail:
Title:  Amino acids     Volume:  35     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Health and Human Performance Laboratory, The University of Montana, Missoula, MT 59812-1825, USA.
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MeSH Terms
Amino Acids / administration & dosage
Blood Glucose / analysis,  drug effects
Dietary Carbohydrates / administration & dosage*
Glycogen / analysis,  biosynthesis*
Isoleucine / administration & dosage,  analogs & derivatives*
Muscle, Skeletal / chemistry,  drug effects,  metabolism
Plant Extracts / administration & dosage*
Seeds / chemistry
Trigonella / chemistry*
Reg. No./Substance:
0/4-hydroxyisoleucine; 0/Amino Acids; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Plant Extracts; 73-32-5/Isoleucine; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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