Document Detail


Glycogen phosphorylase isoenzyme BB to diagnose ischaemic myocardial damage.
MedLine Citation:
PMID:  9581859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycogen phosphorylase isoenzyme BB (GPBB) is a key enzyme of glycogenolysis. Its degree of association with the sarcoplasmatic reticulum glycogenolysis complex depends essentially on the metabolic state of the myocardium. With the onset of tissue hypoxia, when glycogen is broken down, GPBB is converted from a structurally bound into a cytoplasmatic form. Considerable amounts of GPBB are only found in human heart and brain. In the first clinical studies GPBB was the most sensitive marker for the diagnosis of acute myocardial infarction within 4 h of chest pain onset. GPBB also increases early in patients with unstable angina and reversible ST-T alterations in the resting electrocardiogram at hospital admission, which could be useful for risk stratification. GPBB is sensitive for the detection of perioperative ischaemic myocardial damage and infarction in patients undergoing coronary artery bypass grafting. The diagnostic specificity of GPBB in non-traumatic chest pain patients was comparable to creatine kinase MB. These results indicate that GPBB is a sensitive marker for ischaemic myocardial damage.
Authors:
J Mair
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  272     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  79-86     Citation Subset:  IM    
Affiliation:
Institut für Medizinische Chemie und Biochemie, Innsbruck, Austria. johannes.mair@uibk.ac.at
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / enzymology
Coronary Artery Bypass
Humans
Isoenzymes / diagnostic use*
Myocardial Ischemia / diagnosis,  enzymology,  pathology*
Phosphorylases / diagnostic use*
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.4.1.-/Phosphorylases

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