Document Detail


Glycogen metabolism and post-exercise ketosis in carbohydrate-restricted trained and untrained rats.
MedLine Citation:
PMID:  2717702     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liver and muscle glycogen, and blood 3-hydroxybutyrate concentrations were studied during and for 2 h after treadmill running for 1 h, in 144 carbohydrate-starved trained and untrained rats. The resting liver glycogen concentration of the trained animals was 227 +/- 8 (mean +/- S.E.M.) mumol glucosyl units/g wet mass, compared with 162 +/- 12 mumol/g in the untrained animals. The muscle glycogen levels were 42 +/- 1 and 28 +/- 1 mumol/g respectively. Exercise reduced muscle and liver glycogen concentrations by approximately the same absolute amounts in both animal groups, leaving the trained rats with nearly 3 times as much residual glycogen as the untrained animals. There was very little resynthesis of muscle glycogen recovery, but the trained animals replenished approximately 43% of the liver glycogen used during exercise. The blood 3-hydroxybutyrate concentrations were negatively correlated with the simultaneous liver glycogen concentration of our experimental animals (r = -0.55; P less than 0.001). It is concluded that trained animals primarily owe their resistance to post-exercise ketosis to their large stores of glycogen.
Authors:
J H Adams; J H Koeslag
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Quarterly journal of experimental physiology (Cambridge, England)     Volume:  74     ISSN:  0144-8757     ISO Abbreviation:  Q J Exp Physiol     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-06-16     Completed Date:  1989-06-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8206873     Medline TA:  Q J Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  27-34     Citation Subset:  IM; S    
Affiliation:
Department of Physiology, University of Cape Town Medical School, Observatory, South Africa.
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxybutyric Acid
Animals
Dietary Carbohydrates
Glycogen / metabolism*
Hydroxybutyrates / blood
Ketosis / etiology
Liver Glycogen / metabolism*
Male
Muscles / metabolism
Physical Conditioning, Animal*
Physical Exertion
Rats
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Hydroxybutyrates; 0/Liver Glycogen; 300-85-6/3-Hydroxybutyric Acid; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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