Document Detail

Glycogen localization in pulmonary vascular smooth muscle of chronically hypoxic rats.
MedLine Citation:
PMID:  7077709     Owner:  NLM     Status:  MEDLINE    
The pulmonary trunk, muscular arteries, and arterioles of male Sprague-Dawley rats exposed to simulated high altitude hypoxia (380 mm Hg) for six weeks were studied for glycogen localization. As early as three days exposure time, glycogen particles were mobilized in the smooth muscle cells of muscular arteries and arterioles. Weekly sacrifice of animals showed increasing preferential accumulation of glycogen, near the sarcoplasmic reticulum, in the subsarcolemmal region, adjacent to micropinocytotic vesicles, and near the mitochondria in the smooth muscle cells of muscular arteries and arterioles. However, in the smooth muscle cells of the pulmonary trunk and newly muscularized vessels (arteries and arterioles), glycogen storage was not readily noted. These results suggests that the vascular energetics responsible for maintaining the pulmonary hypertensive state differ depending on the class of vessel. Also the muscular pulmonary arteries and arterioles which exhibited the greatest change in glycogen metabolism, may be primarily responsible for the maintenance of pulmonary hypertension.
N Migally; A Tucker; J Zambernard
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of submicroscopic cytology     Volume:  14     ISSN:  0022-4782     ISO Abbreviation:  J. Submicrosc. Cytol.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0235232     Medline TA:  J Submicrosc Cytol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM; S    
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MeSH Terms
Anoxia / physiopathology*
Cell Differentiation
Chronic Disease
Glycogen / analysis*
Microscopy, Electron
Muscle, Smooth, Vascular / ultrastructure*
Pulmonary Circulation*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:

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