Document Detail

Glycogen and lactate synthetic pathways in human skeletal muscle in relation to obesity, weight reduction and physical training.
MedLine Citation:
PMID:  3138128     Owner:  NLM     Status:  MEDLINE    
The effects of obesity, weight reduction, and physical condition on the concentrations of glucose-6-phosphate (G-6-P) and glycogen, and the activities of glycogen synthase (GS) and lactate dehydrogenase (LD) were determined in resting vastus or gastrocnemius muscles of 40 healthy subjects. In obese women the activity of GS was 50% (P less than 0.05) lower than in lean women with similar levels of glycogen and G-6-P, whereas no difference was found in the activity of LD. Calorie restriction induced a 4.5% (P less than 0.05) decrease in body weight from 82.5 kg corresponding to a 3.2% (P less than 0.05) decrease in body mass index from 30.9 kg m-2. The total and fractional activities of glycogen synthase were increased by 50% (P less than 0.05), whereas muscle glycogen content was reduced by 40% (P less than 0.05). The G-6-P concentration and the activity of LD remained unchanged. In well-trained young men the concentrations of G-6-P and glycogen were, respectively, 250% (P less than 0.05) and 50% (P less than 0.05) higher than in non-trained. The fractional and total activities of GS were 90% (P less than 0.05) and 50% (P less than 0.05) higher, respectively, and the total activity of LD was only half (P less than 0.05) that of non-trained subjects. In conclusion, physical training enhances the activity of GS, despite a concomitantly increased glycogen content, and thus seems to exert a more efficient stimulus on glycogen synthase than weight reduction. It is indicated that physical training may provide a clinically important contribution to blood glucose reduction in hyperglycaemic conditions.
K Allenberg; M Nilsson; K Landin; F Lindgärde
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  18     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-10-19     Completed Date:  1988-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  250-5     Citation Subset:  IM    
August Krogh Institute, Copenhagen, Denmark.
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MeSH Terms
Body Weight*
Diet, Reducing
Dietary Carbohydrates / administration & dosage
Glycogen / biosynthesis*
Lactates / biosynthesis*
Middle Aged
Muscles / metabolism*
Obesity / metabolism*
Physical Education and Training*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Lactates; 9005-79-2/Glycogen

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