Document Detail


Glycodelin protein and mRNA is downregulated in human first trimester abortion and partially upregulated in mole pregnancy.
MedLine Citation:
PMID:  18256018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycodelin (Gd) is a major reproductive glycoprotein and a mediator for immunomodulatory effects directed to cellular, humoral, and innate immunity. Human pregnancy depends on a diversity of physiological processes including modulation of the maternal immunosystem. We evaluated the expression of Gd protein and mRNA in first trimester decidual tissue of normal pregnancies and spontaneous abortion and hydatidiform moles. Furthermore, in vitro experiments on endometrial cancer cells to analyze the effect of human chorionic gonadotropin (hCG) on Gd regulation were performed. In decidual tissue of abortion patients, Gd expression was significantly decreased compared with normal gestation, which was confirmed by in situ hybridization. In mole pregnancy, an upregulation of Gd in the first 8 weeks of pregnancy was present. Gd is a main product of decidual tissue in the first trimester of human pregnancy. Reduced Gd expression in abortive pregnancy could lead to an increased activation of the maternal immunosystem, thus causing rejection of the developing fetus. Moreover, Gd expression in endometrial cancer cells in vitro could be stimulated by addition of hCG. Therefore, we speculate that hCG could be one of the factors regulating Gd expression because hCG is downregulated in women with abortion and upregulated in mole pregnancy. In addition, we found a positive feedback loop in Gd and hCG expression in human pregnancy.
Authors:
Bettina Toth; Karin Roth; Christiane Kunert-Keil; Christoph Scholz; Sandra Schulze; Ioannis Mylonas; Klaus Friese; Udo Jeschke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-05
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  56     ISSN:  0022-1554     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-05-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  477-85     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology-Innenstadt, Ludwig-Maximilians University, Maistrasse 11, D-80337 Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / genetics*,  immunology,  metabolism
Antibodies, Monoclonal / immunology
Antibody Specificity
Cell Line, Tumor
Chorionic Gonadotropin / genetics,  metabolism
Down-Regulation*
Female
Gene Expression Regulation, Neoplastic*
Glycoproteins / genetics*
Humans
Hydatidiform Mole / genetics*,  immunology,  metabolism
In Situ Hybridization
Pregnancy
Pregnancy Proteins / genetics*
Pregnancy Trimester, First / genetics*,  immunology,  metabolism
RNA, Messenger / genetics,  metabolism
Up-Regulation*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Chorionic Gonadotropin; 0/Glycoproteins; 0/PAEP protein, human; 0/Pregnancy Proteins; 0/RNA, Messenger
Comments/Corrections

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