| Glycochenodeoxycholate induces rat alveolar epithelial type II cell death and inhibits surfactant secretion in vitro. | |
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MedLine Citation:
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PMID: 22569305 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Bile acid induced lung injury has become an important topic for neonatologists after the discovery of high incidence of infant respiratory distress syndrome complicated from maternal intrahepatic cholesistasis. To explore the molecular pathway of bile acid induced lung injury, we investigated the cytotoxicity of the glycochenodeoxycholate (GCDC) to alveolar epithelial type 2 cell (AECII), as the main component of bile acid. The results demonstrated that glycochenodeoxycholate induced oxidative stress, mitochondrial damage, and increased caspase activity in the primary cultured AECII, Moreover, ROS scavengers and caspases inhibitors could rescue cell death induced by GCDC in rat AECII. Our results also indicated that GCDC inhibited AECII surfactant secretion. In conclusion, this study suggested that cell death prevention and cell therapy should be considered as one of the therapeutic strategies to infant respiratory distress syndrome complicated from maternal intrahepatic cholestasis. |
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Authors:
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Hu Zhangxue; Gao Min; Zhao Jinning; Shi Yuan; Wang Li; Song Huapei; Li Ru; Zeng Chunyu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-5 |
Journal Detail:
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Title: Free radical biology & medicine Volume: - ISSN: 1873-4596 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of biochemistry and molecular biology, third military medical university, Chongqing, China, 400038. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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