Document Detail


Glycobiology of the ocular surface: mucins and lectins.
MedLine Citation:
PMID:  23325272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycosylation is an important and common form of posttranscriptional modification of proteins in cells. During the last decade, a vast array of biological functions has been ascribed to glycans because of a rapid evolution in glycomic technologies. Glycogenes that are highly expressed at the human ocular surface include families of glycosyltransferases, proteoglycans, and glycan degradation proteins, as well as mucins and carbohydrate-binding proteins, such as the galectins. On the apical glycocalyx, mucin O-glycans promote boundary lubrication, prevent bacterial adhesion and endocytic activity, and maintain epithelial barrier function through interactions with galectins. The emerging roles attributed to glycans are contributing to the appreciation of their biological capabilities at the ocular surface.
Authors:
Pablo Argüeso
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-17
Journal Detail:
Title:  Japanese journal of ophthalmology     Volume:  57     ISSN:  1613-2246     ISO Abbreviation:  Jpn. J. Ophthalmol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-12     Completed Date:  2013-06-17     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  0044652     Medline TA:  Jpn J Ophthalmol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  150-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Adhesion / physiology
Biological Transport
Cornea / metabolism*
Epithelium, Corneal / metabolism
Galectins / metabolism
Glycocalyx / metabolism
Glycomics*
Glycosylation
Glycosyltransferases / metabolism
Humans
Lectins / physiology*
Mucins / physiology*
Polysaccharides / metabolism
Protein Processing, Post-Translational
Grant Support
ID/Acronym/Agency:
R01 EY014847/EY/NEI NIH HHS; R01EY014847/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Galectins; 0/Lectins; 0/Mucins; 0/Polysaccharides; EC 2.4.-/Glycosyltransferases
Comments/Corrections

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