| Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. | |
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MedLine Citation:
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PMID: 22044190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ischaemia is amongst the leading causes of death. Despite this importance, there are only a few therapeutic approaches to protect from ischaemia-reperfusion injury (IRI). In experimental studies, the amino acid glycine effectively protected from IRI. In the prevention of IRI by glycine in cells and isolated perfused or cold-stored organs (tissues), direct cytoprotection plays a crucial role, most likely by prevention of the formation of pathological plasma membrane pores. Under in vivo conditions, the mechanism of protection by glycine is less clear, partly due to the physiological presence of the amino acid. Here, inhibition of the inflammatory response in the injured tissue is considered to contribute decisively to the glycine-induced reduction of IRI. However, attenuation of IRI recently achieved in experimental animals by low-dose glycine treatment regimens suggests additional/other (unknown) protective mechanisms. Despite the convincing experimental evidence and the large therapeutic width of glycine, there are only a few clinical trials on the protection from IRI by glycine with ambivalent results. Thus, both the mechanism(s) behind the protection of glycine against IRI in vivo and its true clinical potential remain to be addressed in future experimental studies/clinical trials. |
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Authors:
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Frank Petrat; Kerstin Boengler; Rainer Schulz; Herbert de Groot |
Publication Detail:
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Type: In Vitro; Journal Article; Review |
Journal Detail:
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Title: British journal of pharmacology Volume: 165 ISSN: 1476-5381 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-12 Completed Date: 2012-07-23 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 2059-72 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society. |
Affiliation:
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Institut für Physiologische Chemie, Universitätsklinikum Essen, Essen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / drug effects Cells, Cultured Glycine / pharmacology*, physiology* Humans Inflammation / physiopathology, prevention & control Intestine, Small / drug effects Kidney / drug effects Liver / drug effects Models, Biological Organ Preservation / methods Reactive Oxygen Species / metabolism Reperfusion Injury / physiopathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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