Document Detail


Glycine regulates proliferation and differentiation of salivary-gland-derived progenitor cells.
MedLine Citation:
PMID:  19290545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amino acids have various physiological activities that influence processes such as intestinal regeneration, EGF secretion, protein synthesis, and cell growth. Salivary glands are exposed to nutrients that influence their proliferation and regeneration. Glycine is included in saliva in large quantities and reportedly has important roles in antibacterial activities and the inhibition of tumor growth and as a precursor of nucleotide synthesis in cell proliferation. We have investigated the effects of glycine on the proliferation and differentiation of salivary glands by using mouse salivary-gland-derived progenitor (mSGP) cells. In cultures of mSGP cells, cell proliferation is suppressed in the presence of glycine, whereas it is promoted by its removal. Glycine promotes three-dimensional formations of mSGP cells, which are negative for immature markers and positive for differentiation markers. In cell-cycle analysis, cell-cycle progression is delayed at the S-phase by glycine supplementation. Glycine also suppresses the phosphorylation of p42/p44MAPK. These results suggest that glycine suppresses the proliferation and promotes the differentiation of mSGP cells, and that it has inhibitory effects on growth factor signaling and cell-cycle progression. Glycine might therefore be a physiological activator that regulates the proliferation and differentiation of salivary glands.
Authors:
Yasuko Nakamura; Shirou Matsumoto; Taiga Mochida; Kimitoshi Nakamura; Kenji Takehana; Fumio Endo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-17
Journal Detail:
Title:  Cell and tissue research     Volume:  336     ISSN:  1432-0878     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-29     Completed Date:  2009-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Kumamoto University, Graduate School of Medical Sciences, Honjo, Kumamoto City, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Cell Differentiation / drug effects*
Cell Proliferation / drug effects
Cells, Cultured
Flow Cytometry
Glycine / pharmacology*
Mice
S Phase / drug effects
Salivary Glands / cytology*
Stem Cells / cytology*,  drug effects*
Time Factors
Chemical
Reg. No./Substance:
56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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