| Glycine potentiation of anticonvulsant drugs in pentylenetetrazol seizures in rats. | |
| | |
MedLine Citation:
|
PMID: 2015517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study evaluates the glycine potentiation of anticonvulsant drugs in subcutaneous pentylenetetrazol seizures in rats. Administered alone, glycine (30 or 40 mM/kg, PO) induced no anticonvulsant effect or neurological deficit. Coadministered with anticonvulsants, glycine significantly enhanced the anticonvulsant potency of diazepam and sodium valproate without affecting the neurological deficit induced by the anticonvulsants. Glycine did not significantly alter the anticonvulsant activity of ethosuximide or phenobarbital. These findings indicate a possible glycine-sensitive component in the mechanism of action of diazepam and sodium divalproate in subcutaneous pentylenetetrazol seizures. With the possible exception of sodium valproate, the present study provides little support for a glycine and gamma-aminobutyric acid (GABA) interaction as a mechanism of anticonvulsant activity in SC PTZ seizures. Further studies are required to determine the role of strychnine-sensitive and strychnine-insensitive glycine receptors in this experimental model of absence epilepsy. |
| | |
Authors:
|
S L Peterson |
Related Documents
:
|
8281447 - Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure... 1913197 - Loss of dendritic synapses in the medial amygdala associated with kindling. 7268407 - Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children. 12890517 - Neuroprotective activity of antazoline against neuronal damage induced by limbic status... 20171207 - Changes in the level of calcyon mrna in the brain of rats exposed to cocaine, self-admi... 21146287 - The combined toxicity of dibutyl phthalate and benzo(a)pyrene on the reproductive syste... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Brain research bulletin Volume: 26 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1991 Jan |
Date Detail:
|
Created Date: 1991-05-22 Completed Date: 1991-05-22 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 43-7 Citation Subset: IM |
Affiliation:
|
Department of Medical Pharmacology and Toxicology, Texas A&M University, College Station 77843. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anticonvulsants / pharmacology* Drug Synergism Glycine / pharmacology* Male Pentylenetetrazole Rats Rats, Inbred Strains Seizures / chemically induced, drug therapy* |
| Grant Support | |
ID/Acronym/Agency:
|
NS 24566/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 54-95-5/Pentylenetetrazole; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrastructural and morphometric analysis of neurons in the arcuate nucleus of the female rat hypoth...
Next Document: Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns.