Document Detail

Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
MedLine Citation:
PMID:  6442397     Owner:  NLM     Status:  MEDLINE    
The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures. In seizures caused by pentylenetetrazol, glycine potentiated the anticonvulsant effect of phenobarbital only slightly; in combination with dilantin, which was ineffective by itself, it did not have an effect. Valproic acid, in large doses, prevented 3-mercaptopropionic acid-induced seizures; glycine did not potentiate its effect. Glycine thus potentiates anticonvulsant effects, but only of some drugs and only in some of the seizure models. This suggests that the mechanism of the anticonvulsant effect of glycine is similar to that of some of the anticonvulsant drugs such as dilantin and different from others, and that this mechanism is not effective in all seizure models.
E Toth; A Lajtha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurochemical research     Volume:  9     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-05-03     Completed Date:  1985-05-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1711-8     Citation Subset:  IM    
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MeSH Terms
3-Mercaptopropionic Acid
Acoustic Stimulation
Anticonvulsants / therapeutic use*
Disease Models, Animal
Drug Synergism
Glycine / therapeutic use*
Mice, Inbred BALB C
Mice, Inbred DBA
Phenobarbital / therapeutic use
Phenytoin / therapeutic use
Seizures / chemically induced,  prevention & control*
Valproic Acid / pharmacology
Reg. No./Substance:
0/Anticonvulsants; 107-96-0/3-Mercaptopropionic Acid; 50-06-6/Phenobarbital; 54-95-5/Pentylenetetrazole; 56-40-6/Glycine; 57-41-0/Phenytoin; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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