| Glycine conjugation of the substituted benzoic acids in mice: structure-metabolism relationship study II. | |
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MedLine Citation:
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PMID: 1812276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycine conjugation of a series of substituted benzoic acids was investigated in the mouse liver and kidney mitochondria. Correlations between the structure of 24 substituted benzoic acids and glycine conjugation were obtained. The extent of glycine conjugation of a series of substituted benzoic acids in liver mitochondria was different from that in kidney mitochondria. Glycine conjugation increased with greater lipid solubility in the mouse liver and kidney. The steric effect of the substituent had a far greater influence over the glycine conjugation in kidney, while the size of the substituent played a small role in the pattern of conjugation in liver. The formation of the glycine conjugate in liver was also dependent on the substituent electronegativity. |
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Authors:
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F Kasuya; K Igarashi; M Fukui |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmacobio-dynamics Volume: 14 ISSN: 0386-846X ISO Abbreviation: J. Pharmacobio-dyn. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-06-10 Completed Date: 1992-06-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7901854 Medline TA: J Pharmacobiodyn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 671-7 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Science, Kobe-gakuin University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzoates / metabolism* Benzoic Acid Chromatography, High Pressure Liquid Glycine / metabolism* Kidney / metabolism* Male Mice Mitochondria / metabolism* Mitochondria, Liver / metabolism* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Benzoates; 56-40-6/Glycine; 65-85-0/Benzoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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