Document Detail

Glyceryl trinitrate vs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial.
MedLine Citation:
PMID:  9369106     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study was undertaken to compare local application of a glyceryl trinitrate ointment with lateral internal sphincterotomy for the treatment of chronic fissure-in-ano. PATIENTS AND METHODS: A sample of 24 consecutive patients with chronic anal fissure was randomly allocated to treatment with sphincterotomy or local glyceryl trinitrate. Patients were followed-up for a median of 22 months. RESULTS: All 12 patients healed following sphincterotomy; 10 of 12 healed with local glyceryl trinitrate (P = 0.239). There were no recurrences or side-effects in either group. CONCLUSIONS: Local application of glyceryl trinitrate can avoid surgery in more than 80 percent of patients with chronic anal fissure.
G J Oettlé
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  40     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-03     Completed Date:  1997-12-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1318-20     Citation Subset:  IM    
Department of Surgery, JG Strijdom Hospital and the University of the Witwatersrand, Johannesburg, South Africa.
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MeSH Terms
Administration, Topical
Anal Canal / surgery*
Chronic Disease
Fissure in Ano / therapy*
Follow-Up Studies
Middle Aged
Nitroglycerin / administration & dosage*
Reg. No./Substance:
0/Ointments; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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