| Glyceryl trinitrate vs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial. | |
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MedLine Citation:
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PMID: 9369106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study was undertaken to compare local application of a glyceryl trinitrate ointment with lateral internal sphincterotomy for the treatment of chronic fissure-in-ano. PATIENTS AND METHODS: A sample of 24 consecutive patients with chronic anal fissure was randomly allocated to treatment with sphincterotomy or local glyceryl trinitrate. Patients were followed-up for a median of 22 months. RESULTS: All 12 patients healed following sphincterotomy; 10 of 12 healed with local glyceryl trinitrate (P = 0.239). There were no recurrences or side-effects in either group. CONCLUSIONS: Local application of glyceryl trinitrate can avoid surgery in more than 80 percent of patients with chronic anal fissure. |
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Authors:
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G J Oettlé |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 40 ISSN: 0012-3706 ISO Abbreviation: Dis. Colon Rectum Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1997-12-03 Completed Date: 1997-12-03 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1318-20 Citation Subset: IM |
Affiliation:
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Department of Surgery, JG Strijdom Hospital and the University of the Witwatersrand, Johannesburg, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Anal Canal / surgery* Chronic Disease Female Fissure in Ano / therapy* Follow-Up Studies Humans Male Middle Aged Nitroglycerin / administration & dosage* Ointments |
| Chemical | |
Reg. No./Substance:
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0/Ointments; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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