| Glyceryl trinitrate ointment (0.25%) and anal cryothermal dilators in the treatment of chronic anal fissures. | |
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MedLine Citation:
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PMID: 19367435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Chronic anal fissure is a common benign disorder; for this condition, lateral internal sphincterotomy is the "gold standard" of treatment. Alternative medical treatments have not proven to be as effective as left lateral internal sphincterotomy. AIM: This randomized trial was designed to compare the use of 0.25% glyceryl trinitrate ointment and anal cryothermal dilators with the use of 0.4% glyceryl trinitrate ointment alone in the treatment of chronic anal fissures. METHODS: Between 1 June 2006 and 31 December 2007, 60 consecutive patients who were suffering from chronic anal fissures were randomized into two groups. The patients in group A (n = 30) were treated with 0.25% glyceryl trinitrate ointment and anal cryothermal dilators twice daily, and those in group B (n = 30) were treated with 0.4% glyceryl trinitrate ointment alone twice daily. The treatment was administered to the patients in each group for 6 weeks, and all patients were examined 7 weeks after the start of the trial. RESULTS: Prior to treatment, the symptoms and the measurements of anal pressure were similar in both groups. At 7 weeks, the maximum resting pressure was significantly lower in group A (P < 0.05), in which 86.6% of the patients were asymptomatic in comparison with 73.3% of the patients in group B. After 1 year of follow-up, 25 patients (83.3%) in group A and 18 patients (60%) in group B presented no recurrence of symptoms (P < 0.05) CONCLUSIONS: Treatment of chronic anal fissures with 0.25% glyceryl trinitrate ointment and anal cryothermal dilators was more effective than the administration of 0.4% glyceryl trinitrate ointment alone. |
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Authors:
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Michele Schiano di Visconte; Gabriele Munegato |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2009-04-15 |
Journal Detail:
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Title: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Volume: 13 ISSN: 1873-4626 ISO Abbreviation: J. Gastrointest. Surg. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-09 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706084 Medline TA: J Gastrointest Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1283-91 Citation Subset: IM |
Affiliation:
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General Surgery Department, S. Maria dei Battuti Hospital, Via Brigata Bisagno, 4, 31015, Conegliano (Treviso), Italy. dr.schianodivisconte@tiscali.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adolescent Adult Anal Canal / drug effects* Chronic Disease Cryotherapy / instrumentation* Dilatation / instrumentation* Female Fissure in Ano / diagnosis, therapy* Follow-Up Studies Humans Male Manometry Nitroglycerin / therapeutic use* Ointments Pain Measurement Patient Satisfaction Probability Prospective Studies Risk Assessment Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric Treatment Outcome Wound Healing / physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Ointments; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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